@article { ISI:000344825300009,
	title = {Chiron approach to formal synthesis of both antipodes of cis 3-hydroxypipecolic acid},
	journal = {Tetrahedron Letters},
	volume = {55},
	number = {47},
	year = {2014},
	month = {NOV},
	pages = {6423-6426},
	publisher = {PERGAMON-ELSEVIER SCIENCE LTD},
	type = {Article},
	address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND},
	abstract = {<p>The efficient and practical formal syntheses of both enantiomers of cis 3-hydroxypipecolic acid were accomplished from cis aziridine-2-carboxylate as the common synthetic precursor. The key steps involved are stereo and regioselective aziridine ring opening, reductive cyclization and selective N-debenzylation over O-debenzylation reactions. (C) 2014 Elsevier Ltd. All rights reserved.</p>},
	keywords = {3-Hydroxypipecolic acid, Aziridine ring opening, Aziridine-2-carboxylate, Piperidine alkaloids, Selective debenzylation},
	issn = {0040-4039},
	doi = {10.1016/j.tetlet.2014.09.118},
	author = {Chavan, Subhash P. and Khairnar, Lalit B. and Chavan, Prakash N. and Dumare, Nilesh B. and Kalbhor, Dinesh B. and Gonnade, Rajesh G.}
}
@article {47097,
	title = {Divergent approach to the synthesis of (-)-balanol heterocycle and cis-3-hydroxypipecolic acid based on chiral 2-aminoalkanol equivalent},
	journal = {Tetrahedron},
	volume = {80},
	year = {2021},
	month = {JAN},
	pages = {131773},
	type = {Article},
	abstract = {<p>Enantioselective synthesis of the hexahydroazepine core of (-)-balanol and formal synthesis of cis-3hydroxypipecolic acid from a common intermediate have been accomplished by a divergent path. The common intermediate was accessed from a favorably protected enantiomerically pure 2-amino-1,3,4-butanetriol (ABT) equivalent via oxidation and Wittig olefination. The synthesis of (-)-balanol heterocycle featured tandem reduction/acetal-deprotection/gamma-lactonization reaction and a one-pot azide reduction followed by seven membered aza-heterocycle formation while the route to cis-3-hydroxypipecolic acid highlighted the base induced piperidine ring formation and regioselective benzylidine-acetal cleavage. (C) 2020 Elsevier Ltd. All rights reserved.</p>
},
	keywords = {Amino-alcohol, desymmetrization, Hexahydroazepine, Piperidine alkaloids, Protein kinase},
	issn = {0040-4020},
	doi = {10.1016/j.tet.2020.131773},
	author = {Chavan, Subhash P. and Kalbhor, Dinesh B. and Gonnade, Rajesh G.}
}
