@article {44627,
	title = {Copper- and phosphine-free nickel(II)-catalyzed method for C-H bond alkynylation of benzothiazoles and related azoles},
	journal = {Asian Journal of Organic Chemistry},
	volume = {7},
	year = {2018},
	month = {JUL},
	pages = {1390-1395},
	abstract = {<p>A phosphine-free nickel(II)-catalyzed method for the C(2)-H bond alkynylation of (benzo)thiazoles, (benz)imidazoles, and oxazoles is described. Well-defined and air-stable (Phen)NiCl2 catalyst efficiently catalyzes the coupling of diverse azoles with alkynyl bromides without the use of a copper co-catalyst, and the method tolerates synthetically important functional groups. Preliminary mechanistic studies on this Ni-II-catalyzed alkynylation emphasize the homogeneous nature of the catalyst, and rule out a radical manifold for the reaction. The synthetic utility of this Ni-catalyzed method is demonstrated by further functionalizing the alkynylated benzothiazoles to 3-methyl-2-(alkynyl)benzo[d]thiazolium salts that are known DNA cleaving agents.</p>},
	keywords = {alkynylation, azoles, C-H activation, heterocycles, Nickel},
	issn = {2193-5807},
	doi = {10.1002/ajoc.201800243},
	author = {Patel, Ulhas N. and Punji, Benudhar}
}
@article {49677,
	title = {Nickel-catalyzed regioselective C--H alkynylation of pyridones and isoquinolinones using alkynyl bromides},
	journal = {ChemCatChem},
	volume = {17},
	year = {2025},
	month = {JUN},
	type = {Article},
	abstract = {<p>A straightforward and efficient protocol for the regioselective C \&amp; horbar;H alkynylation of 2-pyridones and isoquinolinones with bromoalkynes under nickel catalysis is described. The alkynylation reaction is enabled by a simple and inexpensive Ni(OTf)2/tBubpy catalyst system and uses easily accessible bromoalkynes. The protocol demonstrates a broad substrate scope with up to 95\% yield (42 examples) and accommodates synthetically valuable functionalities, such as halides, trifluoromethyl, nitrile, ether, thioether, alkyl silanes, and alkene, as well as heteroarene moieties like pyridinyl, furanyl, and thiophenyl. The pyridinyl directing group on alkynylated 2-pyridones can be smoothly removed to give C6-alkynylated free NH-pyridone. Preliminary mechanistic studies suggest that the alkynylation proceeds via a 2e- oxidative addition pathway involving crucial C \&amp; horbar;H activation.</p>
},
	keywords = {alkynylation, C \& horbar, H Activation, Mechanism, Nickel, pyridones},
	issn = {1867-3880},
	doi = {10.1002/cctc.202500338},
	author = {Verma, Suryadev K. and Patil, Harshal R. and Punji, Benudhar}
}
