@article { ISI:000339493400008,
	title = {General approach to N-heterocyclic carbenes with a fused tetracyclic core: ligands for suzuki-miyaura cross-coupling reaction},
	journal = {European Journal of Organic Chemistry},
	number = {21},
	year = {2014},
	month = {JUL},
	pages = {4482-4486},
	publisher = {WILEY-V C H VERLAG GMBH},
	address = {BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY},
	abstract = {<p>The synthesis of an N-heterocyclic carbene (NHC) based on a tetracyclic scaffold by using simple, general, and scalable chemistry is disclosed. The developed route is suitable for introducing multiple substitutions on the tetracyclic scaffold. The utility of the present NHC as a ligand in the Suzuki-Miyaura cross-coupling reaction is demonstrated with a low catalyst loading.</p>},
	keywords = {C-C coupling, carbenes, Homogeneous catalysis, N ligands, synthetic methods},
	issn = {1434-193X},
	doi = {10.1002/ejoc.201402378},
	author = {Sutar, Revannath L. and Kumar, Vinod and Shingare, Rahul D. and Thorat, Shridhar and Gonnade, Rajesh G. and Reddy, D. Srinivasa}
}
@article {42900,
	title = {Repurposing of a drug scaffold: identification of novel sila analogues of rimonabant as potent antitubercular agents},
	journal = {European Journal of Medicinal Chemistry},
	volume = {122},
	year = {2016},
	month = {OCT},
	pages = {723-730},
	abstract = {<p>The structural similarity between an MmpL3 inhibitor BM212, and a cannabinoid receptor modulator rimonabant, prompted us to investigate the anti-tubercular activity of rimonabant and its analogues. Further optimization, particularly through incorporation of silicon into the scaffold, resulted in new compounds with significant improvement in anti-tubercular activity against Mycobacterium tuberculosis (H37Rv). The sila analogue 18a was found to be the most potent antimycobacterial compound (MIC, 31 ng/mL) from this series with an excellent selectivity index. (C) 2016 Elsevier Masson SAS. All rights reserved.</p>},
	doi = {10.1016/j.ejmech.2016.07.009},
	author = {Ramesh, Remya and Shingare, Rahul D. and Kumar, Vinod and Anand, Amitesh and Swetha, B. and Veeraraghavan, Sridhar and Viswanadha, Srikant and Ummanni, Ramesh and Gokhale, Rajesh S. and Reddy, D. Srinivasa}
}
