@article { ISI:000342087400004,
	title = {Discontinuous two step flow synthesis of m-aminoacetophenone},
	journal = {Green Processing and Synthesis},
	volume = {3},
	number = {4},
	year = {2014},
	month = {AUG},
	pages = {279-285},
	publisher = {WALTER DE GRUYTER GMBH},
	type = {Article},
	address = {GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY},
	abstract = {<p>The continuous flow nitration of acetophenone followed by reduction of the meta isomer has been demonstrated using simple tubular reactors. Because of ease of separation of the desired isomer from the first step, both steps are made continuous, but separately. The continuous flow nitration was carried out in a safe manner in a shorter reaction time than the conventional approach. The choice of micromixer was seen to affect the performance of the nitration reaction. The effect of different parameters on the yield of the desired product was studied. The reduction step with sodium sulfide was found to be economical and could be carried out efficiently at 70 degrees C using sodium sulfide in ethanol, using a silicone tube. Both steps were demonstrated for several hours, yielding a sufficiently large quantity (similar to 100 g) of m-aminoacetophenone at lab scale in a single day using simple tubular reactors.</p>},
	keywords = {acetophenone, continuous flow synthesis, microreactor, nitration, reduction},
	issn = {2191-9542},
	doi = {10.1515/gps-2014-0043},
	author = {Tibhe, Jagdish and Sharma, Yachita and Joshi, Ramesh A. and Joshi, Rohini R. and Kulkarni, Amol A.}
}
@article {44193,
	title = {Pressure equalization approach for flow uniformity in microreactor with parallel channels},
	journal = {Chemical Engineering Science},
	volume = {176},
	year = {2018},
	month = {FEB},
	pages = {96-106},
	type = {Article},
	abstract = {<p>Numbering-up using parallel channels helps to achieve higher processing capacity while retaining the advantages of microreactors. However it may also lead to non-uniformity in flow across all the channels. Here we report the CFD simulations and experimental observations on the extent of uniformity in the flow from an assembly of several parallel channels. In the conventional parallel channel geometry, smaller channel size (\&lt;300 m) as well as higher fluid viscosity is seen to give better flow uniformity. Inequality in pressure distribution at the inlet of a large number of parallel channels is overcome by having two {\textquoteleft}pressure equalization slots{\textquoteright} at an equal distance from inlet and outlets that open in the respective manifolds. Having such an arrangement helped to reduce the standard deviation in the flow by almost 90\% when compared to the conventional geometry. However the modification was seen to increase the extent of back mixing to some extent. (C) 2017 Elsevier Ltd. All rights reserved.</p>},
	keywords = {CFD, Experiments, Flow distribution, microreactor, Numbering-up, Parallel channels},
	issn = {0009-2509},
	doi = {10.1016/j.ces.2017.10.021},
	author = {Madane, Ketan and Kulkarni, Amol A.}
}
