@article { ISI:000370450600006,
	title = {Diastereoselective synthesis of beta-ether derivatives of artemisinin, an antimalarial drug: the effect of nitrile on stereoselectivity},
	journal = {Asian Journal of Organic Chemistry},
	volume = {5},
	number = {2},
	year = {2016},
	month = {FEB},
	pages = {201-206},
	publisher = {WILEY-V C H VERLAG GMBH},
	address = {POSTFACH 101161, 69451 WEINHEIM, GERMANY},
	abstract = {<p>Malaria is a life-threatening disease affecting a major portion of the world{\textquoteright}s population with considerable loss of human life. Artemisinin, isolated from Artemisia annua, its oil- and water-soluble derivatives, and other known antimalarials are recommended for artemisinin combination therapy by the World Health Organization. We have established a method for the stereoselective synthesis of beta-ether derivatives of dihydroartemisinin in high yield and high diastereoselectivity. The reaction either in acetonitrile or dichloromethane/trichloroacetonitrile (6:1) mixtures at 0 degrees C or room temperature, respectively, furnished the antimalarial drugs artemether 3 or arteether 4 in high yield with a high diastereomeric ratio. The effect the nitrile has on the yield and stereoselectivity is mechanistically explained.</p>},
	keywords = {antimalarials, arteethers, artemisinin, nitriles, trichloroacetimidates},
	issn = {2193-5807},
	doi = {10.1002/ajoc.201500415},
	author = {Chand, Hemender R. and Bhattacharya, Asish K.}
}
@article {47290,
	title = {3 d transition metal-catalyzed hydrogenation of nitriles and alkynes},
	journal = {Chemistry-An Asian Journal},
	volume = {15},
	year = {2020},
	month = {MAR},
	pages = {690-708},
	type = {Review},
	abstract = {<p>Selective hydrogenation of nitriles and alkynes is crucial considering the vast applications of reduced products in industries and in the synthesis of bioactive compounds. Particularly, the late 3d transition metal catalysts (manganese, iron, cobalt, nickel and copper) have shown promising activity for the hydrogenation of nitriles to primary amines, secondary amines and imines. Similarly, semihydrogenation of alkynes to E- and Z-alkenes by 3d metals is adequately successful both via the transfer hydrogenation and by using molecular hydrogen. The emergence of 3d transition metals in the selective synthesis of industrially relevant amines, imines and alkenes makes this protocol more attractive. Herein, we provide a concise overview on the late 3d transition metal-catalyzed hydrogenation of nitriles to amines and imines as well as semihydrogenation of alkynes to alkenes.</p>},
	keywords = {3d transition metal, Alkynes, Hydrogenation, nitriles, Semihydrogenation},
	issn = {1861-4728},
	doi = {10.1002/asia.201901762, Early Access Date = FEB 2020},
	author = {Sharma, Dipesh M. and Punji, Benudhar}
}
