@article { ISI:000257349100007, title = {Silicate nanoparticles by bioleaching of glass and modification of the glass surface}, journal = {Journal of Non-Crystalline Solids}, volume = {354}, number = {29}, year = {2008}, month = {JUL}, pages = {3433-3437}, publisher = {ELSEVIER SCIENCE BV}, address = {PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS}, abstract = {

Bioleaching is examined as a low temperature (50 degrees C) soft chemical approach to nanosynthesis and surface processing. We demonstrate that fungus based bioleaching of borosilicate glass enables synthesis of nearly monodispersed ultrafine (similar to 5 +/- 0.5 nm) silicate nanoparticles. Using various techniques such as X-ray diffraction, X-ray photoelectron spectroscopy and FTIR we compare the constitution and composition of the nanoparticles with that of the parent glass, and establish the basic similarities between the two. The bioleaching process is shown to enhance the non-bridging oxygen component and correspondingly influence the Si-O-Si network. The root mean square roughness of glass surface is seen to increase from 1.27 nm for bare glass to 2.52 nm for 15 h fungal processed case, this increase being equivalent to that for glass annealed at 500 degrees C. (c) 2008 Elsevier B.V. All rights reserved.

}, keywords = {Bioglass, Biomaterials, borosilicates, narroparticles}, issn = {0022-3093}, doi = {10.1016/j.jnoncrysol.2008.03.025}, author = {Kulkarni, Sneha and Syed, Asad and Singh, Sanjay and Gaikwad, Anil and Patil, Kashinath and Vijayamohanan, K. and Ahmad, Absar and Ogale, Satishchandra} } @article { ISI:000303178600058, title = {Green synthesis of TiO2 nanoparticles by using aqueous extract of Jatropha curcas L. latex}, journal = {Materials Letters}, volume = {75}, year = {2012}, month = {MAY}, pages = {196-199}, publisher = {ELSEVIER SCIENCE BV}, address = {PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS}, abstract = {

Present study deals with a green synthesis of TiO2 nanoparticles by using 0.3\% aqueous extract prepared from latex of Jatropha curcas L. TiO2 nanoparticles were characterized by X-ray diffraction (XRD), Selected Area Electron Diffraction (SAED), Transmission Electron Microscopy (TEM), Energy Dispersive Analysis of X-rays (EDAX) and Fourier Transform Infrared Spectroscopy (FTIR). Fourier Transform Infrared Spectroscopy (FTIR) were performed to find the role of curcain (enzyme), cyclic peptides namely curcacycline A (an octapeptide) and curcacycline B (a nonapeptide) as a possible reducing and capping agents, present in the latex of J. curcas L. The average size of TiO2 nanoparticles was found to be in the range of 25 to 100 nm. Our result shows that there are two broad categories of nanoparticles, first having diameter from 25 to 50 nm which are mostly spherical in shape and second having some larger and uneven shapes. (C) 2012 Elsevier B.V. All rights reserved.

}, keywords = {Biomaterials, Electron microscopy, Fourier Transform Infrared Spectroscopy (FTIR), Nanostructures}, issn = {0167-577X}, doi = {10.1016/j.matlet.2012.02.018}, author = {Hudlikar, Manish and Joglekar, Shriram and Dhaygude, Mayur and Kodam, Kisan M.} } @article { ISI:000335434600004, title = {Thermoresponsive and biodegradable dextran based microgels: synthesis and structural investigation}, journal = {Macromolecular Symposia}, volume = {329}, number = {1}, year = {2013}, note = {Polymer Networks Conference (PNG), WY, AUG 12-16, 2012}, month = {JUL}, pages = {27-34}, publisher = {WILEY-V C H VERLAG GMBH}, address = {BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY}, abstract = {

Nanostructured objects, often ranging from hundreds of nanometers to few microns, support a number of functions directly linked to their structural features. They are, or they will be, protagonists in biomedical applications where miniaturized activities are required. These include the interface with living systems as tissues and cells, where targeted release of drug molecules occurs, or molecular imaging methods monitoring the drug trafficking in specific cell districts. The potentials of such devices, far to be fully understood, will be assessed only when a close correlation of their functions with their structure will be established. In this contribution we present a dextran based microdevice responsive to temperature and biodegradable. Both thermoresponsivity and biodegradability are of relevance for the potential use as drug carrier and controlled release device. The temperature behaviour, overall structure and internal architectures have been addressed with different methods.

}, keywords = {Biomaterials, colloids, dynamic light scattering, hydrogels, p(NiPAAm)}, issn = {1022-1360}, doi = {10.1002/masy.201300009}, author = {Ghugare, Shivkumar V. and Chiessi, Ester and Sakai, Victoria Garcia and Telling, Mark T. F. and Wadgaonkar, Prakash P. and Paradossi, Gaio} } @article { ISI:000338818800044, title = {Biological synthesis of cationic gold nanoparticles and binding of plasmid DNA}, journal = {Materials Letters}, volume = {129}, year = {2014}, month = {AUG}, pages = {159-161}, publisher = {ELSEVIER SCIENCE BV}, type = {Article}, address = {PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS}, abstract = {

Nanobiotechnology is the development of eco-friendly experimental processes for the synthesis of nanomaterials. The present work focuses on synthesis of cationic gold nanoparticles (C-GNPs) for biological applications, especially in gene and drug delivery studies. A biosynthesis methodology has been developed for the functionalization of gold nanoparticles to cationic nature. The synthesis of C-GNPs was done by using peanut leaf extract in the presence of cysteamine. The formed C-GNPs were characterized by using UV-visible spectroscopy (UV-vis), the particles sizes and shapes were confirmed by a Transmission electron microscope (TEM) and crystallinity of C-GNPs was characterized by diffraction. The binding of plasmid DNA on the C-GNPs was confirmed by agarose gel electrophoresis. (C) 2014 Elsevier B.V. All rights reserved.

}, keywords = {Biomaterials, Cationic, Nanoparticles, Plasmid DNA, synthesis, TEM}, issn = {0167-577X}, doi = {10.1016/j.matlet.2014.05.021}, author = {Raju, D. and Vishwakarma, Rishi K. and Khan, Bashir Mohammad and Mehta, Urmil J. and Ahmad, Absar} } @article {47622, title = {Manipulating hydrophobicity of polyester nanofiber mats with egg albumin to enhance cell interactions}, journal = {Polymer Engineering and Science}, volume = {61}, year = {2021}, month = {OCT}, pages = {2496-2510}, type = {Article}, abstract = {A hybrid of poly-l-lactic acid (PLA) and poly-epsilon-caprolactone (PCL) system was designed using hydrophilic generally regarded as safe (GRAS) protein, egg albumin (EA), and fabricated as nanofiber mats (NM) to facilitate improved cell interactions and functionality. Our studies include, preparation and analysis of physicochemical properties of NM. Surface morphology of NM was smooth with the diameter ranging from 250 to 400 nm. The contact angle of NM decreased from 80 to 45 degrees with the increase in EA concentration. The rate and extent of swelling was increased 3-folds with the addition of EA. Release studies of NM showed maximum amount of MTz was released with the increase in MTz concentration (>85\%). The MTz interaction with EA and structure stability of EA was confirmed from fluorescence and circular dichroism studies. NM showed increase in inhibition of bacterial growth of Staphylococcus aureus and Escherichia coli with the increase in MTz concentration. Cell viability of the NM was >80\% and also, the cell proliferation increased as EA content increased. NM hemolytic activity was less than 5\% suggesting compatibility. Hence, results concluded that EA had regulated hydrophobicity, promoted cell interactions, and proliferation and therefore, NM is considered safe for tissue regeneration.}, keywords = {Biocompatibility, Biomaterials, drug delivery systems, egg albumin, electrospinning, nanofibers, polyesters}, issn = {0032-3888}, doi = {10.1002/pen.25776}, author = {Patel, Pratikshkumar R. and Pandey, Komal and Killi, Naresh and Gundloori, Rathna Venkata Naga} } @article {48316, title = {Controlled synthesis of thermosensitive tunable porous film of (pNIPAM)-b-(PCL) copolymer for sustain drug delivery}, journal = {Journal of Applied Polymer Science}, volume = {140}, year = {2023}, month = {MAY}, pages = {e53854}, type = {Article}, abstract = {

There have been reports on different types of porous polymer films for various applications. The designing of such porous films with uniform properties is a challenging task. In this work, tunable porous thin films of poly(N-isopropylacrylamide) (pNIPAM) and polycaprolactone (PCL), that is, (pNIPAM)-b-(PCL) has been fabricated and its sustained drug delivery applications have been reported. First, the (pNIPAM)-b-(PCL) has been synthesized through the addition polymerization of pNIPAM and PCL. Then the synthesized (pNIPAM)-b(PCL) has been used to design porous thin film with varying temperatures without using any external template, below and above the lower critical solution temperatures (LCST) of pNIPAM. Pore size in (pNIPAM)-b-(PCL) films has been tuned by varying the temperature from similar to 10 to 40 degrees C. Then the developed thermosensitive porous film has been taken and seeded with the K562 (chronic myeloid leukemia blood cancer) and HepG2 (hepatocarcinoma) cells and the skin cancer cells (B16-F10) killing efficiency of anticancer drug (e.g., doxorubicin hydrochloride, DOX) loaded (pNIPAM)-b-(PCL) film has been studied. It is found that the DOX-loaded (pNIPAM)-b-(PCL) can efficiently kill the skin cancer cells. The porous polymer thin film reported in this work can be a versatile platform for the loading of drugs and it can be used for the various therapeutic applications.

}, keywords = {Biomaterials, Biomedical Applications, drug delivery systems, films, nanostructured polymers}, issn = {0021-8995}, doi = {10.1002/app.53854}, author = {Amgoth, Chander and Patra, Sukanya and Wasnik, Kirti and Maity, Pradip and Paik, Pradip} }