01616nas a2200193   4500008004100000022001400041245014700055210006900202260000800271300001200279490000700291520087500298100002101173700002301194700002901217700002601246700002301272856012701295       2020                        eng d  a0340-428500aBio-surfactant: a green and environmentally benign reaction medium for ligand-free Pd-catalyzed Mizoroki-Heck cross-coupling reaction in water0 aBiosurfactant a green and environmentally benign reaction medium  cSEP  a403-4110 v453 a<p>A simple and efficient protocol for the ligand-free Mizoroki-Heck coupling reaction of various aryl bromides with different olefins has been reported by using in situ generated PdNPs of size 5-10 nm in aqueous solution of bio-surfactant. The bio-surfactant used in this study is a saponin extract of the seeds of pericarps (pods) of theAcacia concinnaplant. The in situ generated PdNPs have been characterized by various techniques such as HRTEM, EDS and XPS. The influence of various parameters such as the nature and amount of bases, the nature of Pd precatalysts as well as the effect of temperature has been investigated on Mizoroki-Heck coupling reaction. The generated PdNPs significantly coupled the various aryl bromides with different olefins in aqueous extract of the seeds of pericarps (pods) of theAcacia concinnaplant at 100 degrees C. [GRAPHICS] .</p>
1 aPatil, Seema, P.1 aJadhav, Sanjay, N.1 aRode, Chandrashekhar, V.1 aShejwal, Rajendra, V.1 aKumbhar, Arjun, S.  uhttp://library.ncl.res.in/content/bio-surfactant-green-and-environmentally-benign-reaction-medium-ligand-free-pd-catalyzed02643nas a2200265   4500008004100000022001400041245013600055210006900191260000800260300001400268490000800282520168600290653002501976653004102001653002202042653003902064653001902103100002302122700002102145700002402166700001902190700002102209700002902230856011802259       2020                        eng d  a1011-372X00aOrganocatalytic cascade knoevenagel-michael addition reactions: direct synthesis of polysubstituted 2-amino-4H-chromene derivatives0 aOrganocatalytic cascade knoevenagelmichael addition reactions di  cAUG  a2331-23510 v1503 a<p>In this report, we documented novel strategy for the synthesis of bioactive polysubstituted 2-amino-4H-chromine derivatives under a heterogeneous Al-MCM-41-LDH@APTES (ALAM) catalysis. A synthetic procedure is developed to prepare Al-MCM-41-LDH@APTES (ALAM) heterogeneous basic catalysts. Mesoporous Al-MCM-41 is functionalized by known grafting chemistry via layered double hydroxide (LDH) nanosheets and (3-aminopropyl)triethoxysilane (APTES) moiety as a basic organocatalyst. The resulting catalysts contain amino group functionality on the external surface as well as inside the layers and the basicity can be tuned by the loading of APTES. The samples were fully characterized by Si-29 and C-13 CP/MAS NMR, infrared absorption spectroscopy, TEM, XPS, EDX, TGA, XRD, CO2-TPD, N-2 adsorption isotherms measurements, and they were successfully examined for the cascade type Knoevenagel-Michael addition reactions. The product yields associated with these substrates were optimized, and key reaction parameters affecting the yields were identified. The present catalytic method is simple and robust for diversity oriented synthesis which proceeds good to excellent yields without generating any hazards waste. The broad substrate scope, excellent functional group compatibility makes this protocol highly useful towards synthesis of polysubstituted alpha-cyanoacrylates, alpha-cyanoacrylonitriles and 2-amino-4H-chromenes with an electron-donating or electron-withdrawing group. We have also successfully established a flow reaction system, gram-scale synthesis as well as catalyst recyclability up to six catalytic cycles without appreciable loss of its activity. Graphic</p>
10a2-Amino-4H-chromines10aAmine functionalized solid catalysts10acascade synthesis10aDiversity oriented syntheses (DOS)10aflow chemistry1 aJadhav, Sanjay, N.1 aPatil, Seema, P.1 aSahoo, Dipti, Prava1 aRath, Dharitri1 aParida, Kulamani1 aRode, Chandrashekhar, V.  uhttp://library.ncl.res.in/content/organocatalytic-cascade-knoevenagel-michael-addition-reactions-direct-synthesis