01952nas a2200241   4500008004100000022001400041245011200055210006900167260000800236300001400244490000700258520110100265653003301366653003001399653002601429653001401455653002301469653001701492100002401509700002601533700002301559856012801582       2020                        eng d  a1083-616000aEfficient processing of reactions involving diazonium salts: meerwein arylation in an impinging-jet reactor0 aEfficient processing of reactions involving diazonium salts meer  cSEP  a1658-16640 v243 a<p>This work reports a novel approach for performing high-throughput synthesis of Meerwein arylation in an impingingjet reactor. The multistep reaction was performed in a single reactor via in situ diazonium salt generation followed by Meerwein arylation. The work involves many iterations between experiments and simulations (where we integrate simulating the flow, heat transfer, and reaction simultaneously) for optimization of conditions in an inverted impinging-jet reactor. The effect of design variables viz. catalyst concentration, inlet temperature, and monomer mole ratio on the yield of the desired product was studied in detail, and the simulation results were used to plan the continuous experiments. An infrared camera was used to monitor the transient reactor temperature for steady-state analysis. The lab-scale inverted impinging-jet reactor with over 93% isolated yield can offer a space-time yield of 277.78 tons/m(3)/day. The numbering-up of an inverted impinging-jet reactor can be an effective way for cleaner production of products through typical Meerwein arylation.</p>
10acomputational fluid dynamics10ahigh throughput synthesis10aimpinging-jet reactor10aIR camera10aMeerwein arylation10aNumbering-up1 aShukla, Chinmay, A.1 aAtapalkar, Ranjit, S.1 aKulkarni, Amol, A.  uhttp://library.ncl.res.in/content/efficient-processing-reactions-involving-diazonium-salts-meerwein-arylation-impinging-jet02142nas a2200241   4500008004100000022001400041245010300055210006900158260000800227300001200235490000700247520126500254653003301519653003501552653003001587653002901617100002801646700002301674700002601697700002401723700002301747856013001770       2025                        eng d  a1083-616000aConfined impinging jet reactor for high-throughput continuous flow mononitration of salicylic acid0 aConfined impinging jet reactor for highthroughput continuous flo  cJAN  a479-4890 v293 a<p>
	Novel approach is reported for highly efficient continuous mononitration of salicylic acid using confined impinging jet reactor (CIJR) with a vent. Initially, controlled semibatch reactions are optimized to achieve complete conversion and formation of mononitro products with very high selectivity for 5-nitrosalicylic acid (5-NSA). Further, the combination of computational fluid dynamics simulations and experiments is employed to optimize CIJR design and operating flow conditions, suitable to yield only mononitro products with excellent control over mixing, heat transfer, and liberation of fumes during continuous flow reaction. Detailed analysis of internal flow patterns, rate of heat generation, and concentration distribution inside the CIJR facilitated the optimization of present exothermic reaction in a safe manner. In less than a minute, complete salicylic acid (SA) conversion with good yield and better selectivity for 5-NSA is achieved using the CIJR. Safety and clogging issues are addressed effectively, even at a relatively lower mole ratio (1:5) of SA:acetic acid (AcOH). The present approach is quite scalable using the numbering-up strategy, with advantages viz. nonfouling, high throughput, and the small footprint of CIJR.</p>
10acomputational fluid dynamics10aconfined impinging jet reactor10ahigh-throughput synthesis10asalicylic acid nitration1 aKhan, Muzammilanwar, S.1 aShaikh, Tabrez, R.1 aKulkarni, Sphurti, P.1 aPatil, Abhishek, A.1 aKulkarni, Amol, A.  uhttp://library.ncl.res.in/content/confined-impinging-jet-reactor-high-throughput-continuous-flow-mononitration-salicylic-acid