01753nas a2200229   4500008004100000022001400041245009400055210006900149260000800218300001100226490000800237520101900245653000801264653001601272653002201288653001701310653001701327653002201344100001801366700002301384856011601407       2018                        eng d  a0009-250900aPressure equalization approach for flow uniformity in microreactor with parallel channels0 aPressure equalization approach for flow uniformity in microreact  cFEB  a96-1060 v1763 a<p>Numbering-up using parallel channels helps to achieve higher processing capacity while retaining the advantages of microreactors. However it may also lead to non-uniformity in flow across all the channels. Here we report the CFD simulations and experimental observations on the extent of uniformity in the flow from an assembly of several parallel channels. In the conventional parallel channel geometry, smaller channel size (&lt;300 m) as well as higher fluid viscosity is seen to give better flow uniformity. Inequality in pressure distribution at the inlet of a large number of parallel channels is overcome by having two `pressure equalization slots' at an equal distance from inlet and outlets that open in the respective manifolds. Having such an arrangement helped to reduce the standard deviation in the flow by almost 90% when compared to the conventional geometry. However the modification was seen to increase the extent of back mixing to some extent. (C) 2017 Elsevier Ltd. All rights reserved.</p>10aCFD10aExperiments10aFlow distribution10amicroreactor10aNumbering-up10aParallel channels1 aMadane, Ketan1 aKulkarni, Amol, A.  uhttp://library.ncl.res.in/content/pressure-equalization-approach-flow-uniformity-microreactor-parallel-channels01952nas a2200241   4500008004100000022001400041245011200055210006900167260000800236300001400244490000700258520110100265653003301366653003001399653002601429653001401455653002301469653001701492100002401509700002601533700002301559856012801582       2020                        eng d  a1083-616000aEfficient processing of reactions involving diazonium salts: meerwein arylation in an impinging-jet reactor0 aEfficient processing of reactions involving diazonium salts meer  cSEP  a1658-16640 v243 a<p>This work reports a novel approach for performing high-throughput synthesis of Meerwein arylation in an impingingjet reactor. The multistep reaction was performed in a single reactor via in situ diazonium salt generation followed by Meerwein arylation. The work involves many iterations between experiments and simulations (where we integrate simulating the flow, heat transfer, and reaction simultaneously) for optimization of conditions in an inverted impinging-jet reactor. The effect of design variables viz. catalyst concentration, inlet temperature, and monomer mole ratio on the yield of the desired product was studied in detail, and the simulation results were used to plan the continuous experiments. An infrared camera was used to monitor the transient reactor temperature for steady-state analysis. The lab-scale inverted impinging-jet reactor with over 93% isolated yield can offer a space-time yield of 277.78 tons/m(3)/day. The numbering-up of an inverted impinging-jet reactor can be an effective way for cleaner production of products through typical Meerwein arylation.</p>
10acomputational fluid dynamics10ahigh throughput synthesis10aimpinging-jet reactor10aIR camera10aMeerwein arylation10aNumbering-up1 aShukla, Chinmay, A.1 aAtapalkar, Ranjit, S.1 aKulkarni, Amol, A.  uhttp://library.ncl.res.in/content/efficient-processing-reactions-involving-diazonium-salts-meerwein-arylation-impinging-jet