03001nas a2200265 4500008004100000022001400041245014400055210006900199260000800268300001400276490000800290520209300298653001502391653000802406653003602414653001202450653001902462653001502481653002302496100001802519700001802537700002702555700002302582856013002605 2023 eng d a0022-354900aAptamer tethered bio-responsive mesoporous silica nanoparticles for efficient targeted delivery of paclitaxel to treat ovarian cancer cells0 aAptamer tethered bioresponsive mesoporous silica nanoparticles f cMAY a1450-14590 v1123 a

Ovarian cancer is the leading cause of cancer deaths in female patients. The current therapeutics in ovarian cancer are limited and inefficient in curing the disease. To tackle this, we have synthesized tetrasulfide deriv-ative of silica doped, biodegradable, glutathione-responsive targeted mesoporous silica nanoparticles modi-fied with heterobifunctional polyethylene glycol as a linker and mucin-1 aptamer for triggered paclitaxel delivery to the ovarian cancer cells. Degradable mesoporous silica nanoparticles were synthesized by a modi-fied sol-gel method with tetraethyl orthosilicate and Bis (triethoxysilylpropyl) tetrasulfide. The degradable mesoporous silica nanoparticles were characterized by dynamic light scattering, Fourier-transform infrared spectroscopy, Scanning electron microscopy and Transmission electron microscopy. The degradable mesopo-rous silica nanoparticles had good paclitaxel encapsulation efficiency and glutathione-responsive paclitaxel release ability. The glutathione utilization assay and visual destruction observed within 10 days in transmis-sion electron microscopy images confirmed the degradation of the mesoporous silica nanoparticles in the tumor cell environment. The targeted degradable mesoporous silica nanoparticles were efficiently taken up by ovarian cancer cell lines OVACAR-3 and PA-1. The cytotoxicity of bare mesoporous silica nanoparticles evaluated on NIH-3T3 cell line showed good biocompatibility (>90% cell viability). Significant toxicity on OVACAR-3 (IC50 25.66 nM) and PA-1 (IC50 42.93 nM) cell lines was observed when treated with paclitaxel-loaded targeted degradable mesoporous silica nanoparticles. Results of this study demonstrated that mucin-1 targeted, glutathione-responsive mesoporous silica nanoparticles loaded with paclitaxel had a significant antitumor effect on ovarian cancer cells. All these findings demonstrated that developed nano-formulation could be suitable for ovarian cancer treatment. & COPY; 2023 American Pharmacists Association. Published by Elsevier Inc. All rights reserved.

10aDegradable10aGSH10aMesoporous silica nanoparticles10aMucin-110aOvarian cancer10aPaclitaxel10aStimuli-responsive1 aSalve, Rajesh1 aKumar, Pramod1 aChaudhari, Bhushan, P.1 aGajbhiye, Virendra uhttp://library.ncl.res.in/content/aptamer-tethered-bio-responsive-mesoporous-silica-nanoparticles-efficient-targeted-delivery01851nas a2200217 4500008004100000022001400041245013200055210006900187260000800256490000800264520105300272653001601325653002401341653003601365653003001401653001801431100002401449700002001473700002201493856011801515 2023 eng d a1387-181100aEfficient olefin epoxidation with high turnover rates over ordered mesoporous silica nanoparticles with uniform manganese sites0 aEfficient olefin epoxidation with high turnover rates over order cDEC0 v3623 a

Olefin epoxidation has been studied over a series of mesoporous manganese silicate nanoparticles and tBuOOH. Partial substitution of Si by Mn in silica framework leads to highly dispersed, distorted Mn(III) sites, confirmed by various physicochemical analyses. High conversion and stable styrene oxide, stilbene oxide and epoxy cyclohexane yield have been achieved with MS75 with 1:1.5 ratio of olefin: oxidant. However, at faster reaction rates lower styrene oxide yield is observed at lower Mn-containing catalyst (MS100). High TON, TOF over manganese sites shows accessible monomeric Mn sites. Attributed to high reactant density at redox-active Mn silicate sites due to facile diffusion across shallow pore depth channels of nanoparticulate om-MSx and surface hydrophobic characteristics. The catalysts were found to be stable under recycling and filtration experiments. The excellent stability against leaching of active manganese species indicates stable sites and good textural properties in om-MSx, essential for extended activity.

10aepoxidation10aManganese silicates10aMesoporous silica nanoparticles10aOrdered mesoporous silica10apH adjustment1 aNegi, Sanjay, Singh1 aKhatri, Prateek1 aSingh, Anand, Pal uhttp://library.ncl.res.in/content/efficient-olefin-epoxidation-high-turnover-rates-over-ordered-mesoporous-silica02264nas a2200253 4500008004100000022001400041245009000055210007000145260000900215300000700224490000800231520140700239653001601646653001901662653003001681653003601711653002001747100002601767700002001793700003001813700002201843700002001865856012501885 2025 eng d a0974-362600aDesign and synthesis of C-α-D-mannopyranoside linked mesoporous silica nanoparticles0 aDesign and synthesis of CαDmannopyranoside linked mesoporous sil cMAR  a210 v1373 a

Mannose functionalized mesoporous silica nanoparticles (MSNs) offer a promising approach for developing more targeted, effective, and safer cancer therapies. For many of the applications, immobilization of carbohydrates like mannose onto MSNs is a crucial aspect, and in most cases, mannose moieties are connected through O-glycosidic linkages that are susceptible to acidic/enzymatic hydrolysis. To generate a stable mannose-functionalized MSN, we designed a novel C(14)-alpha-mannosylated tetradeca-1-yne. The key steps involved in the synthesis of C-mannosylated alkyne are C1-alkynylation of tri-O-acetyl-D-glucal with 1-trimethylsilyl-tetradec-1-yne, followed by stereoselective dihydroxylation and the isomerization of the internal triple bond to a terminal position. This mannose ligand was then immobilized onto azidopropyl-functionalized SBA-15 through the Cu(I)-catalyzed azide-alkyne click (CuAAC) reaction. Various physical techniques such as low-angle powder XRD, N-2 adsorption isotherms (BET), Fourier transform infrared (FTIR), high-resolution transmission electron microscopy (HRTEM), field emission scanning electron microscopy (FE-SEM), and thermogravimetric analysis (TGA) have been employed to characterize this C-mannosyl SBA-15 silica matrix. We evaluated the binding ability of C-mannosyl SBA-15 nanoparticles by using fluorescein-labelled Con-A as a target protein.

10aC-mannoside10aClick reaction10amannose specific proteins10aMesoporous silica nanoparticles10aZipper reaction1 aNechooli, Hemanth, K.1 aRamtenki, Vilas1 aKumar, Chepuri, V. Suneel1 aPrasad, V., B. L.1 aRamana, Chepuri uhttp://library.ncl.res.in/content/design-and-synthesis-c-%CE%B1-d-mannopyranoside-linked-mesoporous-silica-nanoparticles