Concise synthesis of (+/-)-clopidogrel via carboxylation of benzylamine with CO2
| Title | Concise synthesis of (+/-)-clopidogrel via carboxylation of benzylamine with CO2 |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Venkataramasubramanian, V, Sudalai, A |
| Journal | Synthetic Communications |
| Volume | 45 |
| Issue | 18 |
| Pagination | 2099-2105 |
| Date Published | JUN |
| ISSN | 0039-7911 |
| Keywords | Antithrombatic agent, clopidogrel, CO2 insertion, Plavix |
| Abstract | A concise and efficient synthesis of (+/-)-clopidogrel, an antithrombotic agent, is achieved by inserting CO2 at the benzylic position as the key reaction without using any toxic transition metals. The overall yield of the synthetic process is 38% and the salient features include operationally simple process chemistry and fewer steps. |
| DOI | 10.1080/00397911.2015.1061671 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 1.065 |
Divison category:
Chemical Engineering & Process Development