Design and scale-up of continuous di-nitration reaction using pinched tube flow reactor
| Title | Design and scale-up of continuous di-nitration reaction using pinched tube flow reactor |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | Hussain, A, Sharma, M, Patil, S, Acharya, RB, Kute, M, Waghchaure, A, Kulkarni, AA |
| Journal | Journal of Flow Chemistry |
| Volume | 11 |
| Issue | 3 |
| Pagination | 611-624 |
| Date Published | SEP |
| Type of Article | Article |
| ISSN | 2062-249X |
| Keywords | continuous flow, nitration, Pinched tube, RTD, scale-up |
| Abstract | Scale-up of the di-nitration reaction for synthesis of selective herbicide pendimethalin using only nitric acid in continuous flow is presented in this work. This work showcases an approach for smooth scale-up for an herbicide for a production capacity of 50 kg/day using a pinched tube reactor. The approach begins with the batch experiments followed by flow synthesis using a 1/8-inchSS316 helical coil tube where kinetics of the di-nitration was determined, and process optimization was done. Systematic approach was followed for quantification of heat transfer, mass transfer and residence time distribution and scale-up. Detailed scale-up methodology is presented with effect of relevant parameters for successful scale-up. Modular pilot plant with inline quenching, extraction and separation are some of the salient features presented in this work. |
| DOI | 10.1007/s41981-021-00182-1 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.786 |
Divison category:
Chemical Engineering & Process Development