Diastereoselective synthesis of (A±)- epi-subincanadine C
| Title | Diastereoselective synthesis of (A±)- epi-subincanadine C |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Kalshetti, M, Argade, NP |
| Journal | ACS Omega |
| Volume | 3 |
| Issue | 5 |
| Pagination | 5308-5316 |
| Date Published | MAY |
| Type of Article | Article |
| Abstract | Starting from indolylmaleimide, concise and efficient total synthesis of (±)-epi-subincanadine C was described via stereoselective Wittig olefination, base-induced selective mono-prenylation, regioselective Grignard reaction, diastereoselective Pictet–Spengler cyclization, regioselective oxidative carbon–carbon double-bond cleavage, one-pot reductions, and intramolecular cyclization pathway. An attempted synthesis of (±)-subincanadine C via diastereoselective Grignard addition to the α,β-unsaturated γ-lactam or diastereoselective reduction of a carbon–carbon double bond also resulted in yet another route to (±)-epi-subincanadine C. |
| DOI | 10.1021/acsomega.8b00587 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | Not Available |
Divison category:
Organic Chemistry