Efficient synthesis of optically active herbicide (S)-metolachlor via reductive ring opening of 2-methoxymethylaziridine
| Title | Efficient synthesis of optically active herbicide (S)-metolachlor via reductive ring opening of 2-methoxymethylaziridine |
| Publication Type | Journal Article |
| Year of Publication | 2023 |
| Authors | Nalla, V, Mujahid, M, Sasikumar, M, Mujumdar, P, Muthukrishnan, M |
| Journal | Arkivoc |
| Date Published | JUL |
| Type of Article | Article |
| ISSN | 1551-7004 |
| Keywords | Aziridine, Epoxide, Epoxide ring opening, herbicide synthesis, Metolachlor |
| Abstract | An efficient synthesis of a well known chiral herbicide, (S)-metolachlor has been described using 2methoxymethylaziridine ring formation and reductive ring opening as key steps using commercially available (R)-epichlorohydrin. The present protocol delivers the required enantiomer of metolachlor in overall yield of 50.8% and high enantiopurity (>99%). |
| DOI | 10.24820/ark.5550190.p011.954 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 0.9 |
Divison category:
Organic Chemistry
Database:
Web of Science (WoS)