Enantioselective synthesis of (S,S)-ethambutol using proline-catalyzed asymmetric alpha-aminooxylation and alpha-amination
| Title | Enantioselective synthesis of (S,S)-ethambutol using proline-catalyzed asymmetric alpha-aminooxylation and alpha-amination |
| Publication Type | Journal Article |
| Year of Publication | 2006 |
| Authors | Kotkar, SP, Sudalai, A |
| Journal | Tetrahedron-Asymmetry |
| Volume | 17 |
| Issue | 11 |
| Pagination | 1738-1742 |
| Date Published | JUL |
| Type of Article | Article |
| ISSN | 0957-4166 |
| Abstract | An efficient enantioselective synthesis of (S,S)-ethambutol, a tuberculostatic antibiotic, has been achieved in 99% ee via both proline-catalyzed alpha-aminooxylation and alpha-amination of n-butyraldehyde as the key step. (c) 2006 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetasy.2006.06.011 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.108 |
Divison category:
Chemical Engineering & Process Development