Facile synthesis of 1,3-thiazolidin-4-ones as antitubercular agents
| Title | Facile synthesis of 1,3-thiazolidin-4-ones as antitubercular agents |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Subhedar, DD, Shaikh, MH, Arkile, MA, Yeware, A, Sarkar, D, Shingate, BB |
| Journal | Bioorganic & Medicinal Chemistry Letters |
| Volume | 26 |
| Issue | 7 |
| Pagination | 1704-1708 |
| Date Published | APR |
| ISSN | 0960-894X |
| Keywords | Antitubercular, Cytotoxicity, Green protocol, Multicomponent reaction |
| Abstract | We have developed, highly efficient, one-pot, solvent-free, [Et3NH][HSO4] catalyzed multicomponent reaction protocol for the synthesis of 1,3-thiazolidin-4-ones in excellent yields. For the first time, the 1,3-thiazolidin-4-ones were evaluated in vitro for their antimycobacterial activity against Mycobacterium tuberculosis dormant MTB H37Ra and Mycobacterium bovis BCG strains. Among the synthesized basic 1,3-thiazolidin-4-ones, particularly the compounds 4c, 4d, 4e, 4f, 4h, 4i and 4j displays promising antitubercular activity along with no significant cytotoxicity against the cell lines MCF-7, A549 and HCT-116. (C) 2016 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.bmcl.2016.02.056 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.486 |
Divison category:
Organic Chemistry