Favorable 2 '-substitution in the loop region of a thrombin-binding DNA aptamer
| Title | Favorable 2 '-substitution in the loop region of a thrombin-binding DNA aptamer |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Awachat, R, Wagh, AA, Aher, M, Fernandes, M, Kumar, VA |
| Journal | Bioorganic & Medicinal Chemistry Letters |
| Volume | 28 |
| Issue | 10 |
| Pagination | 1765-1768 |
| Date Published | JUN |
| Type of Article | Article |
| Abstract | Simple 2'-OMe-chemical modification in the loop region of the 15mer G-rich DNA sequence GGTTGGTGTGGTTGG is reported. The G-quadruplex structure of this thrombin-binding aptamer (TBA), is stabilized by single modifications (T -> 2'-OMe-U), depending on the position of the modification. The structural stability also renders significantly increased inhibition of thrombin-induced fibrin polymerization, a process closely associated with blood-clotting. (C) 2018 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.bmcl.2018.04.027 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.454 |
Divison category:
Organic Chemistry