Formal syntheses of (2R,3R)-3-hydroxy pipecolic acid and (2R,3S)-3-hydroxy pipecolic acid from L-ascorbic acid
| Title | Formal syntheses of (2R,3R)-3-hydroxy pipecolic acid and (2R,3S)-3-hydroxy pipecolic acid from L-ascorbic acid |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Chavan, SP, Dumare, NB, Pawar, KP |
| Journal | Tetrahedron Letters |
| Volume | 56 |
| Issue | 6 |
| Pagination | 805-807 |
| Date Published | FEB |
| ISSN | 0040-4039 |
| Keywords | 3-Hydroxy pipecolic acid, cyclization, Epimerization, L-Ascorbic acid |
| Abstract | Formal syntheses of both cis and trans 3-hydroxy pipecolic acids is achieved from L-ascorbic acid. Present synthesis describes use of chiral pool approach in which epimerization, Staudinger reaction and Cyclization reactions were employed as key steps. (C) 2014 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetlet.2014.12.103 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.347 |
Divison category:
Organic Chemistry