Formal synthesis of brivaracetam: a key to construct the pyrrolidone scaffold using Pd-catalyzed oxidative cyclization and ring-closing metathesis reaction
| Title | Formal synthesis of brivaracetam: a key to construct the pyrrolidone scaffold using Pd-catalyzed oxidative cyclization and ring-closing metathesis reaction |
| Publication Type | Journal Article |
| Year of Publication | 2019 |
| Authors | Chavan, SP, Kawale, SA, Chavan, PN |
| Journal | Tetrahedron Letters |
| Volume | 60 |
| Issue | 46 |
| Pagination | 151249 |
| Date Published | NOV |
| Type of Article | Article |
| ISSN | 0040-4039 |
| Keywords | Antiepileptic drugs, Pd-catalyzed oxidative cyclization, pyrrolinone, Ring-closing metathesis reaction |
| Abstract | A short and efficient synthetic approach for brivaracetam has been accomplished via two different routes which utilize Pd-catalyzed oxidative cyclization and ring-closing metathesis (RCM) as the key reaction. These two routes are novel, simple, scalable and rely on (E)-pent-2-en-1-ol and valeraldehyde as a commercially available starting material to yield brivaracetam with good overall yield. (C) 2019 Published by Elsevier Ltd. |
| DOI | 10.1016/j.tetlet.2019.151249 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.125 |
Divison category:
Organic Chemistry