Fungi mediated production and practical purification of (R)-(-)-3-quinuclidinol
| Title | Fungi mediated production and practical purification of (R)-(-)-3-quinuclidinol |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Kolet, SP, Jadhav, DD, Priyadarshini, B, Swarge, BN, Thulasiram, HV |
| Journal | Tetrahedron Letters |
| Volume | 55 |
| Issue | 43 |
| Pagination | 5911-5914 |
| Date Published | OCT |
| ISSN | 0040-4039 |
| Keywords | (R)-(-)-3-Quinuclidinol, Amberlite IR-120, Biotransformation, Ion exchange resin, Mucor pinformis |
| Abstract | A fungal system belonging to Mucoraceae family (Mucor piriformis) was explored for the asymmetric reduction of a prochiral ketone, 3-quinuclidinone (I) in an efficient manner to produce an important pharmaceutical precursor (R)-(-)-3-quinuclidinol (II) with similar to 96% enantiomeric excess. The efficiency of the process was improved by developing a cation exchange resin (Amberlite IR-120) which assisted the purification of water soluble metabolite II from fermentation media. (C) 2014 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetlet.2014.09.015 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.68 |
Divison category:
Organic Chemistry