Novel one-pot multi-component synthesis of 3,3 `-disubstituted oxindole and spirooxindole scaffolds via Sn-catalyzed C(sp(3))-H functionalization of azaarenes by sequential Knoevenagel-Michael-cyclization reaction
| Title | Novel one-pot multi-component synthesis of 3,3 `-disubstituted oxindole and spirooxindole scaffolds via Sn-catalyzed C(sp(3))-H functionalization of azaarenes by sequential Knoevenagel-Michael-cyclization reaction |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Chavan, SS, Pathan, MY, Thorat, SH, Gonnade, RG, Mulla, SAbdul Rash |
| Journal | RSC Advances |
| Volume | 5 |
| Issue | 99 |
| Pagination | 81103-81107 |
| Date Published | SEP |
| ISSN | 2046-2069 |
| Abstract | Sn-catalyzed C(sp(3))-H bond functionalization of 2-methyl azaarenes/2-(azaaryl)methanes has been achieved for the first time in a one-pot multi-component reaction with isatin and active methylene compounds via tandem sequential Knoevenagel-Michael-intramolecular C-N cyclization. This strategy provides new cost-effective access to potent and biologically/medicinally important spirooxindoles/3,3'-disubstituted 2-oxindoles in good to excellent yields. |
| DOI | 10.1039/c5ra16334j |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.289 |
Divison category:
Center for Material Characterization (CMC)
Chemical Engineering & Process Development