Organocatalytic sequential alpha-amination-horner-wadsworth-emmons olefination of aldehydes: enantioselective synthesis of gamma-amino-alpha,beta-unsaturated esters
| Title | Organocatalytic sequential alpha-amination-horner-wadsworth-emmons olefination of aldehydes: enantioselective synthesis of gamma-amino-alpha,beta-unsaturated esters |
| Publication Type | Journal Article |
| Year of Publication | 2007 |
| Authors | Kotkar, SP, Chavan, VB, Sudalai, A |
| Journal | Organic Letters |
| Volume | 9 |
| Issue | 6 |
| Pagination | 1001-1004 |
| Date Published | MAR |
| Type of Article | Article |
| ISSN | 1523-7060 |
| Abstract | A novel and highly enantioselective method for the synthesis of gamma-amino-alpha,beta-unsaturated esters via tandem alpha-amination-Horner-Wadsworth-Emmons (HWE) olefination of aldehydes is described. The one-pot assembly has been demonstrated for the construction of functionalized chiral 2-pyrrolidones, subunits present in several alkaloids. |
| DOI | 10.1021/ol063012j |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 6.732 |
Divison category:
Chemical Engineering & Process Development