Oxone promoted dehydrogenative Povarov cyclization of N-aryl glycine derivatives: an approach towards quinoline fused lactones and lactams
| Title | Oxone promoted dehydrogenative Povarov cyclization of N-aryl glycine derivatives: an approach towards quinoline fused lactones and lactams |
| Publication Type | Journal Article |
| Year of Publication | 2019 |
| Authors | More, DA, Shinde, GH, Shaikh, AC, Muthukrishnan, M |
| Journal | RSC Advances |
| Volume | 9 |
| Issue | 52 |
| Pagination | 30277-30291 |
| Date Published | SEP |
| Type of Article | Article |
| Abstract | Oxone promoted intramolecular dehydrogenative imino Diels-Alder reaction (Povarov cyclization) of alkyne tethered N-aryl glycine esters and amides has been explored, thus affording biologically significant quinoline fused lactones and lactams. The reaction is simple, scalable, and high yielding (up to 88%). The method was further extended to prepare biologically important luotonin-A analogues and the quinoline core of uncialamycin. |
| DOI | 10.1039/c9ra06212b |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.049 |
Divison category:
Organic Chemistry