Pd-catalyzed regioselective mono-arylation: quinazolinone as the inherent directing group for C(sp(2))-H activation
| Title | Pd-catalyzed regioselective mono-arylation: quinazolinone as the inherent directing group for C(sp(2))-H activation |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Garad, DN, Viveki, AB, Mhaske, SB |
| Journal | Journal of Organic Chemistry |
| Volume | 82 |
| Start Page | 6366-6372 |
| Issue | 12 |
| Pagination | 6366-6372 |
| Date Published | JUN |
| Type of Article | Article |
| ISSN | 0022-3263 |
| Keywords | Aromatic rings, catalysis, Chemical activation, Chemical reactions, Palladium compounds, Regioselectivity |
| Abstract | The Pd-catalyzed quinazolinone-directed regioselective monoarylation of aromatic rings by C-H bond activation is developed. A broad substrate scope is demonstrated for both quinazolinone as well as diary-liodonium triflates. The use of a base was found to be crucial for this transformation, unlike for the known nitrogen-directed arylations. All of the novel quinazolinones of biological interest were synthesized by using the operationally simple Pd(II)-catalyzed arylation reaction. |
| DOI | 10.1021/acs.joc.7b00948 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 4.785 |
Divison category:
Organic Chemistry