PNAs grafted with (alpha/gamma, R/S)-aminomethylene pendants: Regio and stereo specific effects on DNA binding and improved cell uptake
| Title | PNAs grafted with (alpha/gamma, R/S)-aminomethylene pendants: Regio and stereo specific effects on DNA binding and improved cell uptake |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Mitra, R, Ganesh, KN |
| Journal | Chemical Communications |
| Volume | 47 |
| Issue | 4 |
| Pagination | 1198-1200 |
| Date Published | JAN |
| ISSN | 1359-7345 |
| Abstract | PNAs grafted with cationic aminomethylene (am) pendants on the backbone at the glycyl (alpha) or ethylenediamine (gamma) segments show regio (alpha/gamma) and stereochemistry (R/S) dependent binding with complementary DNA. These are efficiently taken up by cells, with gamma(S-am) aeg-PNA being the best in all properties. |
| DOI | 10.1039/c0cc03988h |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 5.96 |
Divison category:
Organic Chemistry