Short enantioselective synthesis of the antiepileptic agent, levetiracetam based on proline-catalyzed asymmetric alpha-aminooxylation
| Title | Short enantioselective synthesis of the antiepileptic agent, levetiracetam based on proline-catalyzed asymmetric alpha-aminooxylation |
| Publication Type | Journal Article |
| Year of Publication | 2006 |
| Authors | Kotkar, SP, Sudalai, A |
| Journal | Tetrahedron Letters |
| Volume | 47 |
| Issue | 38 |
| Pagination | 6813-6815 |
| Date Published | SEP |
| Type of Article | Article |
| ISSN | 0040-4039 |
| Abstract | An efficient enantioselective synthesis of a new antiepileptic drug, levetiracetam is described, in high optical purity (> 99.5% ee), using proline-catalyzed alpha-aminooxylation of n-butyraldehyde as the key step. (c) 2006 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetlet.2006.07.061 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.347 |
Divison category:
Chemical Engineering & Process Development