Three in one: prototropy-free highly stable AADD-type self-complementary quadruple hydrogen-bonded molecular duplexes with built-in fluorophore
| Title | Three in one: prototropy-free highly stable AADD-type self-complementary quadruple hydrogen-bonded molecular duplexes with built-in fluorophore |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Kheria, S, Rayavarapu, S, Kotmale, AS, Sanjayan, GJ |
| Journal | Chemical Communications |
| Volume | 53 |
| Issue | 18 |
| Date Published | FEB |
| Type of Article | Article |
| Abstract | This communication reports an effective approach for addressing the prototropy-related problems in heterocycle-based AADD-type self-assembling systems by freezing their hydrogen-bonding codes, by utilizing intramolecular bifurcated hydrogen bonding interactions. Using this strategy, we have also developed a hydroquinone-conjugated AADD-type self-assembling system adorned with three valuable features such as prototropy-free dimerization yielding single duplexes, high duplex stability and a built-in fluorophore, which would augment its application potential. The rational approach used herein to arrest prototropic shift may also find application elsewhere, wherein proton shift-mediated structural changes become a detrimental factor. |
| DOI | 10.1039/C6CC09478C |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 6.567 |
Divison category:
Organic Chemistry