Enantioselective synthesis of (+)-hygroline and (+)-pseudohygroline via Keck allylation and CBS reduction
| Title | Enantioselective synthesis of (+)-hygroline and (+)-pseudohygroline via Keck allylation and CBS reduction |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Bhoite, SP, Kamble, RB, Suryavanshi, GM |
| Journal | Tetrahedron Letters |
| Volume | 56 |
| Issue | 32 |
| Pagination | 4704-4705 |
| Date Published | AUG |
| ISSN | 0040-4039 |
| Keywords | CBS reduction, Keck allylation, Pyrrolidines, Wacker oxidation |
| Abstract | An enantioselective synthesis of (+)-hygroline and (+)-pseudohygroline has been achieved in high optical purity (98% ee) from readily available 1,4-butanediol. The synthesis strategy employs a Keck allylation, CBS reduction, and Wacker oxidation. (C) 2015 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetlet.2015.06.012 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.347 |
Divison category:
Chemical Engineering & Process Development