Concise enantioselective synthesis of marine macrolide-stagonolide E via organocatalysis
| Title | Concise enantioselective synthesis of marine macrolide-stagonolide E via organocatalysis |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Dey, S, Sudalai, A |
| Journal | Tetrahedron-Asymmetry |
| Volume | 26 |
| Issue | 7 |
| Pagination | 344-349 |
| Date Published | APR |
| ISSN | 0957-4166 |
| Abstract | A short and efficient enantioselective synthesis of marine macrolide stagonolide E in high enantiomeric purity (98% ee and 8.5% overall yield) starting from commercially available raw materials has been achieved. The strategy involves proline catalyzed sequential alpha-aminooxylation and Horner-Wadsworth-Emmons olefination, highly stereoselective Ando's cis-olefination, and modified Yamaguchi macrolactonization as the key reaction steps. (C) 2015 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetasy.2015.03.001 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.108 |
Divison category:
Chemical Engineering & Process Development