Metal-free regioselective C-3 acetoxylation of N-substituted indoles: crucial impact of nitrogen-substituent
| Title | Metal-free regioselective C-3 acetoxylation of N-substituted indoles: crucial impact of nitrogen-substituent |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Soni, V, Patel, UN, Punji, B |
| Journal | RSC Advances |
| Volume | 5 |
| Issue | 71 |
| Pagination | 57472-57481 |
| Date Published | JUN |
| ISSN | 2046-2069 |
| Abstract | A metal-free method for the regioselective C-3 acetoxylation of the N-substituted indoles with PhI(OAc)(2) is described under mild reaction conditions. This method tolerates a broad range of functional groups with moderate to good yields. The pi-electron-deficient aryl-substituents on the N-atom of indoles and the acidic reaction medium remarkably favor C-3 acetoxylation. |
| DOI | 10.1039/c5ra10428a |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.289 |
Divison category:
Chemical Engineering & Process Development