Optically pure gamma-butyrolactones and epoxy esters via two stereocentered HKR of 3-substituted epoxy esters: a formal synthesis of (-)-paroxetine, Ro 67-8867 and (+)-eldanolide
| Title | Optically pure gamma-butyrolactones and epoxy esters via two stereocentered HKR of 3-substituted epoxy esters: a formal synthesis of (-)-paroxetine, Ro 67-8867 and (+)-eldanolide |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Devalankar, DA, Karabal, PU, Sudalai, A |
| Journal | Organic & Biomolecular Chemistry |
| Volume | 11 |
| Issue | 8 |
| Pagination | 1280-1285 |
| Date Published | JAN |
| ISSN | 1477-0520 |
| Abstract | The HKR of racemic anti- or syn-3-substituted epoxy esters catalyzed by a Co(III)salen complex provides ready access to the corresponding enantioenriched 3,4-disubstituted gamma-butyrolactones and 3-substituted epoxy esters. This strategy has been successfully employed in the formal synthesis of biologically active 3,4-disubstituted piperidine derivatives, (-)-paroxetine and Ro 67-8867 and a natural product, (+)-eldanolide. |
| DOI | 10.1039/c3ob27321k |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.487 |
Divison category:
Chemical Engineering & Process Development