Efficient synthesis of benzofuranones: N-heterocyclic carbene (NHC)/base-catalyzed hydroacylation-stetter-rearrangement cascade
| Title | Efficient synthesis of benzofuranones: N-heterocyclic carbene (NHC)/base-catalyzed hydroacylation-stetter-rearrangement cascade |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Padmanaban, M, Biju, AT, Glorius, F |
| Journal | Organic Letters |
| Volume | 13 |
| Issue | 20 |
| Pagination | 5624-5627 |
| Date Published | OCT |
| ISSN | 1523-7060 |
| Abstract | A N-heterocyclic carbene/base-catalyzed cascade reaction leading to the formation of functionalized benzofuranones is reported. The reaction proceeds via an intramolecular hydroacylation of unactivated alkynes followed by an intermolecular Stetter reaction and a base-catalyzed chromanone to benzofuranone rearrangement. |
| DOI | 10.1021/ol2023483 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 6.17 |
Divison category:
Organic Chemistry