Cu(OTf)(2) or Et3N-catalyzed three-component condensation of aldehydes, amines and cyanides: a high yielding synthesis of alpha-aminonitriles
| Title | Cu(OTf)(2) or Et3N-catalyzed three-component condensation of aldehydes, amines and cyanides: a high yielding synthesis of alpha-aminonitriles |
| Publication Type | Journal Article |
| Year of Publication | 2006 |
| Authors | Paraskar, AS, Sudalai, A |
| Journal | Tetrahedron Letters |
| Volume | 47 |
| Issue | 32 |
| Pagination | 5759-5762 |
| Date Published | AUG |
| Type of Article | Article |
| ISSN | 0040-4039 |
| Keywords | aldehydes, aminonitriles, multicomponent reactions, organocatalyst, Strecker reaction |
| Abstract | Copper(II) triflate or Et3N have been found to catalyze, under ambient conditions, the addition of a cyanide anion, such as trimethylsilyl cyanide or acetone cyanohydrin, onto in situ generated imines, furnishing alpha-aminonitriles in excellent yields. (c) 2006 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetlet.2006.06.008 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.347 |
Divison category:
Chemical Engineering & Process Development