Microwave assisted fast and clean conversion of mesylate to azide: synthesis of (1S,2R/1R,2S)-1-azido-2-carbocyclic amines as immediate precursors to versatile 1,2-cis-diamines
| Title | Microwave assisted fast and clean conversion of mesylate to azide: synthesis of (1S,2R/1R,2S)-1-azido-2-carbocyclic amines as immediate precursors to versatile 1,2-cis-diamines |
| Publication Type | Journal Article |
| Year of Publication | 2006 |
| Authors | Govindaraju, T |
| Journal | Indian Journal of Chemistry Section B-Organic Chemistry including Medicinal Chemistry |
| Volume | 45 |
| Issue | 6 |
| Pagination | 1492-1498 |
| Date Published | JUN |
| Type of Article | Article |
| ISSN | 0376-4699 |
| Keywords | asymmetric catalysis, Azide, diamines, medicinal agent, mesylate, microwave irradiation |
| Abstract | An efficient and rapid conversion of mesylate to azide under microwave irradiation has been carried out. It proceeds through inversion of configuration from chiral mesylates to provide optically pure cis-azides, immediate precursors of vicinal-cis-1,2-diamines. These diamines can serve as metal ligands in asymmetric catalysis and their derivatives can be employed as medicinal agents. |
| Type of Journal (Indian or Foreign) | Indian |
| Impact Factor (IF) | 0.471 |
Divison category:
Organic Chemistry