Hydroxyl directed C-arylation: synthesis of 3-hydroxyflavones and 2-phenyl-3-hydroxy pyran-4-ones under transition-metal free conditions
| Title | Hydroxyl directed C-arylation: synthesis of 3-hydroxyflavones and 2-phenyl-3-hydroxy pyran-4-ones under transition-metal free conditions |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Paula, S, Bhattacharya, AK |
| Journal | Organic & Biomolecular Chemistry |
| Volume | 16 |
| Issue | 3 |
| Pagination | 444-451 |
| Date Published | JAN |
| Type of Article | Article |
| ISSN | 1477-0520 |
| Abstract | An efficient, transition-metal free and direct C-arylation of 3-hydroxychromone moieties in the presence of a base, air as an oxidant and arylhydrazines as arylating agents to furnish highly biologically active flavonols or 3-hydroxyflavones has been developed. We have further extended our methodology for the C-arylation of the 5-hydroxy pyran-4-one moiety. The role of the free hydroxyl group towards C-arylation has been delineated. |
| DOI | 10.1039/c7ob01929g |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.564 |
Divison category:
Organic Chemistry