Tris-hydroxymethylaminomethane (THAM): An efficient organocatalyst in diversity-oriented and environmentally benign synthesis of spirochromenes
| Title | Tris-hydroxymethylaminomethane (THAM): An efficient organocatalyst in diversity-oriented and environmentally benign synthesis of spirochromenes |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Khot, SS, Anbhule, PV, Desai, UV, Wadgaonkar, PP |
| Journal | Comptes Rendus Chimie |
| Volume | 21 |
| Issue | 9 |
| Pagination | 814-821 |
| Date Published | JUN |
| Type of Article | Article |
| ISSN | 16310748 |
| Keywords | green chemistry, Multicomponent synthesis, organocatalysis, Spirochromenes, Tris-hydroxymethylaminomethane |
| Abstract | Tris-hydroxymethylaminomethane has been demonstrated to be an efficient organocatalyst in diversity-oriented synthesis of medicinally prevalent spirochromenes by one-pot, three-component reactions between isatins, malononitrile, and enolizable CH acids like dimedone, 4-hydroxycoumarin, 4-hydroxy-N-methylquinolin-2-one, or in situ generated 2-methylpyrazolon-2-one. Biodegradability and extremely low cost of the catalyst are the noteworthy features of this chromatography-free protocol. |
| DOI | 10.1016/j.crci.2018.05.005 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 1.879 |
Divison category:
Polymer Science & Engineering