Chirality induction and chiron approaches to enantioselective total synthesis of alpha-lipoic acid
| Title | Chirality induction and chiron approaches to enantioselective total synthesis of alpha-lipoic acid |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Chavan, SP, Pawar, KP, Praveen, C, Patil, NB |
| Journal | Tetrahedron |
| Volume | 71 |
| Issue | 24 |
| Pagination | 4213-4218 |
| Date Published | JUN |
| Type of Article | Article |
| ISSN | 0040-4020 |
| Keywords | Chiral pool, Chirality induction, enantioselective, Lipoic acid, sharpless asymmetric dihydroxylation |
| Abstract | An efficient, short and convenient asymmetric synthesis of (R)-(+)-lipoic acid in seven steps from chiral hydroxy aldehyde with 32.5% overall yield is described. Synthesis of S and R enantiomers of a-lipoic acid from cis-1,4-butene diol derived chiral lactone is reported with 34 % overall yield. The present synthesis involves use of simple reaction conditions making it a convenient synthesis. (C) 2015 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tet.2015.04.090 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.347 |
Divison category:
Organic Chemistry