Ligand-enabled gold-catalyzed C(sp(2))-n cross-coupling reactions of aryl iodides with amines
| Title | Ligand-enabled gold-catalyzed C(sp(2))-n cross-coupling reactions of aryl iodides with amines |
| Publication Type | Journal Article |
| Year of Publication | 2019 |
| Authors | Akram, MO, Das, A, Chakrabarty, I, Patil, NT |
| Journal | Organic Letters |
| Volume | 21 |
| Issue | 19 |
| Pagination | 8101-8105 |
| Date Published | OCT |
| Type of Article | Article |
| ISSN | 1523-7060 |
| Abstract | The first example of ancillary (P,N)-ligand-enabled gold-catalyzed C-N cross-coupling reactions of aryl iodides with amines is reported. The high generality of the reaction in de novo synthesis, late-stage modifications, and cascade processes to access functionalized indolinones and carbazoles underscores the synthetic potential of the presented strategy. Monitoring the reaction with ESI-HRMS and NMR provided strong evidence for the in situ formation of putative high valent Au(III) intermediates. |
| DOI | 10.1021/acs.orglett.9b03082 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 6.555 |
Divison category:
Organic Chemistry