Scalable synthesis of 3-Ethyl-4-methyl-1,5-dihydro-2H-pyrrol-2-one: an important building block of the antidiabetic drug glimepiride
| Title | Scalable synthesis of 3-Ethyl-4-methyl-1,5-dihydro-2H-pyrrol-2-one: an important building block of the antidiabetic drug glimepiride |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Chavan, SP, Pawar, AA, Patil, NB, Kadam, AL, Shinde, SS |
| Journal | Synthesis-Stuttgart |
| Volume | 52 |
| Issue | 22 |
| Pagination | 3480-3484 |
| Date Published | NOV |
| Type of Article | Article |
| ISSN | 0039-7881 |
| Keywords | antidiabetic drug, Butenolide, glimepiride, lactams, scalable synthesis |
| Abstract | A four-step, practical, and easily scalable synthesis of 3-ethyl-4-methyl-1,5-dihydro-2H-pyrrol-2-one, an important building block of the antidiabetic drug glimepiride, has been accomplished. Key features are the synthesis of 3-methyl-4-hydroxy-2-butenolide in water and triflic acid mediated N-benzyl lactam N-deprotection. The main advantages of this process are the scalable synthetic route and decreased number of reaction steps, which paves the way for the industrial-scale synthesis of 3-ethyl-4-methyl-1,5-dihydro-2H-pyrrol-2-one. |
| DOI | 10.1055/s-0040-1707344 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.675 |
Divison category:
Organic Chemistry