One-pot oxidation of secondary alcohols to alpha-hydroxy ketones: application to synthesis of oxoaplysinopsin D, E, F, & G
| Title | One-pot oxidation of secondary alcohols to alpha-hydroxy ketones: application to synthesis of oxoaplysinopsin D, E, F, & G |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | Kulkarni, AS, Ramesh, E, D. Reddy, S |
| Journal | European Journal of Organic Chemistry |
| Volume | 2021 |
| Issue | 15 |
| Pagination | 2188-2192 |
| Date Published | APR |
| Type of Article | Article |
| ISSN | 1434-193X |
| Keywords | alpha-Hydroxylation, Hydantoin, Natural product, Oxoaplysinopsin, Retro-aldol |
| Abstract | A simple one-pot transformation of secondary alcohols to alpha-hydroxy ketones using pyridinium dichromate (PDC) in DMF has been developed and substrate scope tested with 25 compounds of hydantoin derivatives. Using this method, we have devised a common dihydroxy intermediate and synthesized four natural products oxoaplysinopsins D, E, F, and G for the first time. |
| DOI | 10.1002/ejoc.202100184 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.021 |
Divison category:
Organic Chemistry